Cancer resistance, high molecular weight hyaluronic acid, and longevity
نویسندگان
چکیده
منابع مشابه
High Molecular Weight Hyaluronic Acid Inhibits Fibrosis of Endometrium
BACKGROUND Elevated fibrosis has been found in patients with intrauterine adhesion, which indicates that fibrotic factors may play a critical role in formation of intrauterine adhesion. The aim of this study was to identify the effect of hyaluronic acid (HA) at high and low molecular weight on fibrosis of the endometrium in a mouse model of Asherman's syndrome. MATERIAL AND METHODS Endometrial ...
متن کاملHigh and Low Molecular Weight Hyaluronic Acid Differentially Regulate Human Fibrocyte Differentiation
BACKGROUND Following tissue injury, monocytes can enter the tissue and differentiate into fibroblast-like cells called fibrocytes, but little is known about what regulates this differentiation. Extracellular matrix contains high molecular weight hyaluronic acid (HMWHA; ∼2×10(6) Da). During injury, HMWHA breaks down to low molecular weight hyaluronic acid (LMWHA; ∼0.8-8×10(5) Da). METHODS AND ...
متن کاملHigh and low molecular weight hyaluronic acid differentially influence macrophage activation.
Macrophages exhibit phenotypic diversity permitting wide-ranging roles in maintaining physiologic homeostasis. Hyaluronic acid, a major glycosaminoglycan of the extracellular matrix, has been shown to have differential signaling based on its molecular weight. With this in mind, the main objective of this study was to elucidate the role of hyaluronic acid molecular weight on macrophage activatio...
متن کاملHigh-molecular-weight hyaluronic acid attenuated matrix metalloproteinase-1 and -3 expression via CD44 in tendinopathy
Evidence indicates that hyaluronic acid (HA) mitigates tendinopathy, but the effect of molecular weight is unclear. We investigated the effects of different concentrations and different molecular weights of HA (350 kDa, 1500 kDa, and 3000 kDa) on matrix metalloproteinase (MMP)-1 and -3 expression in IL-1β-stimulated rat tenocytes, and on their dynamic expression in peritendinous effusion from p...
متن کامل[Treatment of acute full-thickness chondral defects with high molecular weight hyaluronic acid; an experimental model].
PURPOSE To evaluate the effect of 2 different protocols of intra-articular hyaluronic acid (HA, hylan G-F20) to articular cartilage regeneration in acute full-thickness chondral defects. MATERIALS AND METHODS Full-thickness chondral defects of 3 x 6 mm were performed into the lateral femoral condyles of New Zealand rabbits, treated with a single or three doses of HA. The animals were sacrifie...
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ژورنال
عنوان ژورنال: Journal of Cell Communication and Signaling
سال: 2015
ISSN: 1873-9601,1873-961X
DOI: 10.1007/s12079-015-0278-6